The paradigm for cardiovascular effects of hormonal contraceptives

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Zsuzsanna Ilona Katalin de Jármy Di Bella
J. Bras. Patol. Med. Lab. 2018;54(1):4


Hormonal contraceptives revolutionized the world in the 1960s, allowing women to separate sexual intercourse from procreation. However, since then, doubts exist over the long-term negative side-effects of hormonal contraceptives. Arterial thromboembolic phenomena were soon associated with the estrogen dose of the first pills, as well as alterations in the hepatic lipid profile, the synthesis of sex hormone-binding globulin (SHBG) and the clotting factors(1).

In the following decades, new formulations were successfully released, reducing the dose of ethinylestradiol, associating it to more selective progestogens, what caused fewer arterial cardiovascular events. Read more…